lacosamide side effects heart

2 min read 11-12-2024

Lacosamide is an anti-seizure medication prescribed for epilepsy. While generally well-tolerated, some individuals experience cardiovascular side effects. This article explores the potential cardiac risks associated with lacosamide use, emphasizing the importance of consulting your doctor.

Understanding Lacosamide's Mechanism and Potential Cardiac Impact

Lacosamide works by affecting sodium channels in the brain, reducing neuronal excitability and preventing seizures. However, these sodium channels also exist in the heart. This overlap means there's a theoretical possibility of cardiac side effects. It's crucial to understand that the incidence of serious cardiac events is relatively low.

Commonly Reported Cardiac Side Effects

While rare, some individuals taking lacosamide report these cardiovascular side effects:

Bradycardia (slow heart rate): This is a decrease in heart rate below the normal range.
Palpitations: A sensation of a rapid, fluttering, or irregular heartbeat.
Prolonged QT interval: This refers to a delay in the repolarization phase of the heart's electrical cycle, potentially leading to dangerous heart rhythms. This is a more serious side effect.
Atrial fibrillation (AFib): An irregular and often rapid heart rhythm originating in the atria (upper chambers of the heart).

Less Frequent but Serious Cardiac Events

Although uncommon, more severe cardiac events have been associated with lacosamide in some cases. These include:

Heart block: Disruption of the electrical signals that coordinate the heartbeat.
Ventricular arrhythmias: Irregular heartbeats originating in the ventricles (lower chambers of the heart).

Who is at Higher Risk?

Certain individuals may be at a higher risk of experiencing lacosamide-related heart problems. These include people with pre-existing heart conditions such as:

Congenital long QT syndrome: A genetic disorder causing prolonged QT intervals.
Bradycardia: Individuals already experiencing a slow heart rate.
Heart failure: Weakening of the heart's ability to pump blood effectively.
Other conduction disturbances: Problems with the electrical system of the heart.

What to Do if You Experience Cardiac Symptoms

If you experience any concerning cardiac symptoms while taking lacosamide, such as:

Chest pain
Shortness of breath
Dizziness
Fainting

Stop taking the medication immediately and seek medical attention. Do not hesitate to contact your doctor or go to the emergency room.

Monitoring and Management

Your doctor will likely monitor your heart rhythm during treatment with lacosamide, especially if you have pre-existing heart conditions or risk factors. This may involve electrocardiograms (ECGs) to check your heart's electrical activity.

Conclusion: Lacosamide and Heart Health

While the risk of serious cardiac complications from lacosamide is low, it's essential to be aware of the potential side effects. Open communication with your doctor is crucial. They can assess your individual risk factors, monitor your heart health, and make informed decisions about your treatment plan. Never hesitate to report any concerning symptoms. This proactive approach will help ensure your safety and well-being while managing your epilepsy. Remember, this information is for educational purposes and should not replace professional medical advice. Always consult your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen.